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LAMARC (Likelihood Analysis with Metropolis Algorithm using Random Coalescence; Kuhner 2006)
is a package of programs for computing population parameters,
such as population size, a recombination rate, population exponential growth rate and migration rates by
using likelihoods for samples of data (DNA or RNA sequences, SNPs, or microsatellites) from populations. It approximates the
summation of likelihood over all possible gene genealogies that could
explain the observed sample. The programs are memory-intensive but
can run effectively on workstations or modern microcomputers. The
package is continually expanding and more executables for different
machines will become available soon. LAMARC currently has four core
functions; estimation of the effective population size, estimation of
the exponential growth rate of a single growing population, estimation of migration rates, and estimation of per-site recombination rate of n populations.
These estimates are calculated using microsatellite data or enzyme
electrophoretic data (Beerli 2006).
Version 2.1
Input data file format
PHYLIP
Instructions
To run LAMARC locally, type the program name at a terminal window prompt:
lamarc
To convert phylip files into the XML format required for LAMARC, use the converter. Type
lam_conv
Files for the Workshop tutorial:
On-line documentation is available from the LAMARC website.
Meaning of the g paramater in LAMARC 
Pluzhnikov & Donnelly (1996) describe the relationship between sample size and genetic variation when making experimental design decisions.
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